Congo Red Dot Test

Mamas on Bedrest: A Step Closer to “Curing” Pre-Eclampsia!

October 20th, 2014

IMG_3750 1x13Mamas, Exciting News!!

Researchers at the Center for Perinatal Research at the Nationwide Children’s Hospital in Ohio have identified a Urine test that detects proteins in pregnant mamas’ urine that indicate pre-eclampsia. Pre-Eclampsia is one of the most common reasons mamas are prescribed bed rest, and one of the leading causes of preterm labor, prematurity and even death in mamas globally. This new finding is significant because this current research shows that pre-eclampsia, more specifically the proteins found in the urine of pregnant women with pre-eclampsia, are also associated with diseases of neurodegenerative diseases of aging such as Parkinson’s Disease, Mad Cow Disease and Alzheimers Disease.

Dr. Irina Buhimschi, director of the Center for Perinatal Research at Nationwide Children’s Hospital in Ohio and lead author of the paper. While Dr. Buhimschi admits that this is definitely a huge breakthrough in pre-eclampsia research, she admits that physicians and researchers are still no closer to knowing why some women develop pre-eclampsia and why others don’t. Pre-eclampsia is still responsible for some 75,000 deaths annually, mostly in poorer, developing nations. The proteins noted in mamas’ urine are now easily identified with a simple and inexpensive urine test called the Congo Red Dot Test. This simple test merely requires that clinicians place a small amount of urine on a test paper and if a large red dot develops, they know that the urine contains proteins indicative of pre-eclampsia.While we have reported on the Congo Red Dot test previously, a simple test like the Congo Red Dot test could really be a breakthough in treatment in these areas and significantly lower maternal mortality.

Brenda Torigiani's feet at 7 months.Pre-Eclampsia is diagnosed when a mama has high blood pressure and protein in the urine. Mamas will also often experience facial and extremity swelling. Left untreated, pre-eclampsia leads to dizziness, visual changes, seizures, stroke, swelling and weight gain, organ (kidney) failure and death. Pre-Eclampsia is a leading cause of preterm delivery, yet once the baby and placenta are delivered, mama’s symptoms resolve.

The connection between pre-eclampsia and other neurodegenerative diseases such as Alzheimers has yet to be determined. Additionally, no one yet knows if women who develop pre-eclampsia are at greater risk for developing Alzheimers or Parkinson’s Diseases or have some sort of protection. These questions will definitely have to be answered in subsequent research. In the meantime, having a low technology, easy to perform and inexpensive test to screen for pre-eclampsia may well reduce the maternal mortality associated with it tremendously worldwide. Even here in the US, this low lost, low tech test, performed early, may enable obstetricians to begin treating women early with antihypertensive medications and ward off the more serious signs and symptoms of pre-eclampsia. The next step-or perhaps leap-is that perhaps them mamas who have pre-eclampsia may not need to be placed on bed rest-so long as their blood pressures are stabilized on medications, they are no longer spilling proteins into their urine and they are not having any signs of seizure, stroke or organ failure. Finally, combining these findings with the Pluristem Technology, and yes, we may in fact be on the way to eradicating pre-eclampsia!!

Reference: MacLean’s Digital Magazine

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